An internal standard is a compound added to a sample prior to analysis to aid in quantification of the target analyte(s).It is used to compensate for variations in the sample preparation and/or analytical procedures.An ideal internal standard should be chemically similar to the target analyte(s), but not coelute or interfere with their detection or quantification.
Internal standards are an essential part of many analytical methods.They can improve the accuracy and precision of the analysis, and can also help to identify and correct for errors.